Advanced Joint Support
Derived from meticulous research and development, our Canine Joint Supplement prioritizes the well-being of your dog.
In a market overly saturated with joint supplements of varying quality (Many of which are white labeled with a significant markup), our focus extends beyond mere quantity, emphasizing the quality of our carefully selected ingredients.
This distinction sets our Canine Joint Supplement apart from the majority currently available and from overpriced alternatives that fail to deliver real benefits.
Crafted with a commitment to canine health, our Joint Support Supplement incorporates a blend of bioactive ingredients.
Our supplement, tailored to meet the specific needs of aging dogs or those experiencing a natural slowdown, provides essential support for joint health during this crucial stage of life.
Notably, our formulation caters not only to senior dogs but also proves to be an exceptional choice for canine athletes engaged in the sporting world. Engineered to sustain your active pup's agility and vitality, our joint supplement offers the additional support necessary to keep them in peak condition. Whether your dog is a seasoned athlete, always on the go, or entering their golden years, our Canine Joint Supplement is the ideal solution for promoting and maintaining joint health.
Stop paying for costly joint supplements primarily comprised of inactive ingredients and cheap active ingredients that offer minimal, if any, improvement beyond a placebo effect.
Product information
Our Ingredients
Our specific Collagen Peptides have undergone comprehensive studies, both in vitro and in vivo, involving dogs and horses. Their mechanism of action involves boosting the extracellular cartilage matrix encompassing, Type 2 Collagen, aggrecan, and elastin. Additionally, our collagen peptides contribute to the downregulation of inflammatory cytokines and inhibits multiple protease enzymes, including Matrix Metalloprotease Enzymes (MMP-13), A disintegrins (ADAMTS4, and ADAMTS5.)
The efficacy of our Collagen Peptides have been substantiated through various objective assessments, including magnetic resonance imaging, and measurement of Peak Vertical Force on a treadmill. Additionally, there was a notable reduction in lameness, as evaluated by attending veterinarians, in dogs grappling with osteoarthritis.
What makes Our Collagen Different
Our Collagen has a specific molecular weight and amino acid distribution.
Green Lipped Mussels have undergone extensive studies over the past four decades, revealing a rich composition of active compounds that actively support joint health. These include glycoproteins, fatty acids (omega 3 (EPA, DHA, ETA), and F-Acids), and various glycosaminoglycans (GAGs) such as Glucosamine, Chondroitin, and Hyaluronic Acid. These components play a pivotal role in the construction and repair of articular cartilage, potentially mitigating further joint deterioration.
Research indicates that Green Lipped Mussels possess the ability to modulate inflammatory cytokine levels, including TNF-alpha, IL-1, IL-2, and IL-6, cyclooxygenase enzymes, and Immunoglobulin. Additionally, they contain chondroitin sulfate 4 and 6, hyaluronic acid, and other GAGs, contributing to enhanced flexibility and tensile strength of articular cartilage.
What sets our Green Lipped Mussel apart?
While Green Lipped Mussel Powders may seem interchangeable, there's a critical distinction, and it goes beyond cost. The processing method sets our Green Lipped Mussel powder apart from many others in the market.
While most Green Lipped Mussels are subjected to hot steam pressure cooking in order to open the shells and extract meat, our powder employs a cold extraction process, ensuring it's never exposed to heat.
Additionally, our green lipped mussel powder is not extracted with the use of chemicals or solvents, which can impact the integrity of the active compounds within.
The last key difference between the green-lipped mussel powder we use and others on the market is the attention to time in the processing from fresh, green-lipped mussels to green-lipped mussel powder.
Astaxanthin is a potent antioxidant (~100 times more powerful than the common Vitamin E Isomer Alpha Tocopherol).
What makes astaxanthin unique, however, is its capability to navigate the entire cell, surpassing the conventional confines of the cell membrane or the cell interior.
Astaxanthin extends its impact on joint conditions through the modulation of the Nrf2 and MAPK signaling pathways, thereby slowing the inflammatory cascade, which wreaks havoc on the joints.
Hyaluronic Acid is a non-sulfated glycosaminoglycan (GAG) present in cartilage, synovial fluid, and other tissues. Alongside collagen, it serves as the backbone of proteoglycan aggregates in joint tissue, providing the structural foundation for cartilage.
In its oral form, HA works by interacting with the immune system, triggering the production of new Hyaluronic acid within the joints.
Unlike most joint supplements, we use a patented low-molecular-weight hyaluronic acid, achieved through a fermentation process that does not involve the use of rooster combs.
The significance of molecular weight is underscored by the gastrointestinal tract's ability to absorb Hyaluronic Acid (HA). While it doesn’t take a lot to exert beneficial effects, it does need to be absorbed, and many supplements utilize hyaluronic acid with comparatively high molecular weight.
When scrutinized against these considerations, it renders the inclusion of hyaluronic acid as ineffective in many supplements.
While Vitamin C is most commonly viewed simply as an antioxidant, it does have an important role in joint health as a co-factor in the synthesis of collagen.
MMP Inibition Activity
What sets our Green Lipped Mussel apart?
Matrix Metalloproteinases (MMPs) are a group of enzymes that degrade the extracellular matrix. Unlike most Green Lipped Mussel powders, which aren't tested, ours is tested for Matrix Metalloproteinase Inhibition activity (MMP's 1-14), outperforming other commercially available Green Lipped Mussel Powders by a wide margin.
- This is also why Harper & Friends (our sister company) doesn't make a freeze-dried or dehydrated green lipped mussel treat, because we understand why consumers want to give green lipped mussels, and by the time the green lipped mussels make it to the United States from New Zealand (not Canada as one company claims in an advertisement) that bioactivity is gone. Making it an expensive treat with little health benefits.
No Marketing BS
Why No Glucosamine & Chondroitin
While we wouldn't say glucosamine and chondroitin are useless,
- They are not exactly the most bioavailable compounds, at around 5% and 12%
- Research has increasingly shown that they are not especially efficacious, often performing marginally, if at all, better than a placebo.
- Leading one Meta Analysis to conclude that "Like these previous reviews, the results of the present meta-analysis led to the conclusion that chondroitin-glucosamine nutraceuticals should not be prescribed in canine or feline OA.
- Making them essentially cheap filler ingredients.
- If we never see another advertisement saying we include more glucosamine than competitors, it won't be soon enough
- There are more effective ingredients/compounds.
- There is still glucosamine and chondroitin in our supplement from the green-lipped mussels. Additionally, many chews, i.e., feet, necks, trachea, tendons, etc., are rich in these compounds.
- Additionally, most dog foods contain variable levels of glucosamine and chondroitin naturally based on the ingredients, with some taking the additional step of adding more purified glucosamine and chondroitin.
No Fish Oil, But We Do Highly Recommend an Omega 3 Supplement with EPA and DHA
We intentionally exclude a marine oil rich in EPA and DHA from our product for specific reasons.
- The therapeutic dose required for osteoarthritis, which is relatively high and closely approaches the No Adverse Effect Level.
- Variability of EPA and DHA levels in dog food, treats, and other supplements you may be providing.
- Avoid creating the misconception that adding these essential fatty acids is unnecessary due to their presence in our supplement.
One of our biggest complaints around most joint supplements is that fish oil is often added only for marketing purposes. Ie One Joint Supplement includes 1.2 Mg of fish oil (.56 MG EPA+DHA) for a 30 LBs dog. This low of a dose is having no biological effect.
To illustrate, the therapeutic dose for a 20lbs dog with osteoarthritis is 1623 mgs of EPA and DHA daily. Depending on the current food regimen, your dog might be receiving less than 200 mg or up to 1000 mgs of EPA and DHA daily.
Nevertheless, we provide a fish oil calculator to assist you and your vet in determining the appropriate amount of EPA and DHA based on current scientific literature and the specific dietary composition.
Placebo Effect- Pain Questionnaire
The Placebo Effect is very real. It can be difficult to judge whether a supplement is actually helping. We would all like to believe that the supplements we are providing are helping, but are they?
This is why we include a pain questionnaire designed to help you better judge whether the supplement is actually helping or whether the changes you have noticed are just due to the caregiver effect.
Dosing How Long does it last
Cost
While ours might seem more expensive than other joint supplements, that is due to not only the ingredient quality but also the fact that most supplements contain over 80 percent cheap inactive ingredients. You won't ever see ours 58% off, with a free gift and free shipping, because we aren't charging $38.97 for a supplement whose total cost is only a couple of dollars, and that's being generous with some supplements.